5 Simple Statements About rheumatoid arthritis is an autoimmune disease Explained

The immune system of many people fails to differentiate between healthy cells and invading micro-organisms. This is creating more suffering across the globe. They are being attacked with the immune defenses to diseases that were once there to protect them.




A number of major international research efforts are in place to stop this trend, such as an initiative in London's Francis Crick Institute, where two world experts, James Lee and Carola Vinuesa, have created distinct research groups to pinpoint the precise reasons behind autoimmune diseases in the way that these diseases are well-known.


Lee told the Observer how the number of auto-immune cases has grown over the past 40 years in the West. We are seeing a few cases in countries that have never seen such diseases.


For example the Middle East/east Asia has seen the largest recent rise in inflammatory-bowel disease cases. The patients had never encountered the disease before.


Type 1 diabetes is one of the autoimmune diseases. Other conditions include rheumatoid, inflammation of the bowel, and multiple sclerosis. In each of these cases, your immune system becomes confused and switches to healthy tissue over infectious agents.


The UK has at least 4,000,000 people who have these conditions. There are also numerous others. Globally, it is believed that the number of cases of autoimmune diseases is growing by between 3 and 9 percent each year. Many scientists believe environmental factors are the primary reason for this increase.


Human genetics hasn't changed in the last several years, according to Lee who was located at Cambridge University. Thus, something is changing in our body, which could increase our vulnerability to developing an autoimmune disease.


The idea was supported by Vinuesa who was located at the Australian National University. She highlighted the changes in food habits that were taking place as more countries adopted western-style diets , and consumers bought more fast food.


Vinuesa stated that the lack of certain important ingredients in fast food could result in a decrease in the intake of essential nutrients, including fiber.


These changes to our microbiomes can trigger autoimmune disorders that are of more than 100 kinds.


The scientists both highlighted the importance of individual risk factors for developing such illnesses. Lupus and celiac disease are two other diseases that can cause inflammation and swelling that can cause damage to different organs including your heart.


Vinuesa says that an individual who doesn't have a specific genetic susceptibility to develop an autoimmune disease, regardless of the quantity of Big Macs they eat. There is nothing we can stop the rapid expansion of fast food chains across the globe. Instead, our focus is on understanding the genetic mechanisms that underlie autoimmune disorders and the reasons why certain people are more susceptible to the disease while others are not. "We are trying to address the issue at this level."


Scientists now have the ability to identify tiny differences in the DNA of a large number of people. This is made possible by the use of the development of new methods. This way, it is possible to identify common genetic patterns among those who suffer from an autoimmune condition.


Lee says that although we had the technology for sequencing DNA to the point of being able to sequence DNA, until recent however, it was not possible. When I first began doing research, we knew about half a dozen DNA variations that were involved in triggering an inflammatory bowel disease. Today, we have over 250.


This is at the center of the work done by Lee and Vinuesa. They seek to determine the functions of different genetic pathways and uncover the various kinds of diseases that doctors are currently studying. Vinuesa stated that there are a variety of types of autoimmune diseases including Lupus. This can make it challenging to determine the best treatment.


There are a lot of beneficial therapies being developed constantly however, we aren't sure what patients to recommend these treatments to because we've realized that we don't know for certain which type of disease they suffer from. That's a key goal for the field of autoimmune research. To give the right treatment, we have to understand how to group patients.


Lee explained that, with the rising incidence of autoimmune diseases across the world, new therapies and drugs are now needed more urgently than ever before. It's not possible to cure autoimmune diseases. This is especially true when young people are trying to complete their college education and get their first job, and start families.


It means that an increasing amount of people need to have surgery or will require regular injections throughout their entire lives. It can be devastating for patients and an enormous strain on healthcare services. That's why we need to come up with innovative, efficient solutions.


Rheumatoid is a condition that causes an immune response. This means that the immune system is attacking healthy tissues. We don't know the triggers for it.


The immune system typically produces antibodies that fight against viruses and bacteria, assisting to fight off infection.


If you suffer from Rheumatoid arthritis, the immune system arthritis rheumatoid diet mistakenly sends antibodies to the lining of your joints which target the tissue around the joint.


The thin layer of cells (synovium) that cover your joints, becomes inflamed and painful.


bones

Cartilage is the connective tissue which connects cartilage and bones

Tendons, the tissue connecting bone to muscle

Ligaments are the connective tissue between bone and cartilage.

If the issue is not addressed, it will gradually lead to the loss of alignment and form. Then, eventually, it will cause the joint to be destroyed completely.


There are many theories about how the immune system attacks the joints. For instance an infection could be the trigger. But none of these theories is proven.

Possible risk factors

There are a variety of factors which can increase your risk of developing Read More rheumatoid arthritis, including:


Genes. There are some signs that arthritis rheumatoid may occur in families. But, because genes play only a small part in the condition's development it is not a high likelihood of it being passed to the next generation.

The condition is more prevalent for women than men. It could be due to the estrogen-related effects, however it isn't proven.

Smoking cigarettes is a risk cause for rheumatoid artifiid. A few studies support this.